Entries for the 121st U.S. Open Championship at Torrey Pines (South Course) in San Diego, Calif., are expected to open the fourth week of February. Professionals and amateurs whose Handicap Index does not exceed 1.4 are eligible to enter. All local qualifiers are contested over 18 holes. The following U.S. Open local qualifying sites and dates are subject to change.
| SITE | CITY | STATE | DATE |
| Fox Den Country Club | Knoxville | TN | 4/26/2021 |
| Hoakalei Country Club | Ewa Beach | HI | 4/27/2021 |
| Duke University Golf Club | Durham | NC | 4/27/2021 |
| Huntington Crescent Club | Huntington | NY | 4/27/2021 |
| Waterlefe Golf & River Club | Bradenton | FL | 4/28/2021 |
| Mission Inn Resort & Club (El Campeon Course) | Howey-in-the-Hills | FL | 4/29/2021 |
| Mayacoo Lakes Country Club | West Palm Beach | FL | 4/29/2021 |
| Oakbourne Country Club | Lafayette | LA | 4/29/2021 |
| Columbia Country Club | Blythewood | SC | 4/29/2021 |
| Jackson Country Club | Jackson | TN | 4/29/2021 |
| Amarillo Country Club | Amarillo | TX | 4/29/2021 |
| The Pines Country Club | Morgantown | WV | 4/29/2021 |
| King Kamehameha Golf Club | Wailuku | HI | 5/1/2021 |
| El Niguel Country Club | Laguna Niguel | CA | 5/3/2021 |
| Indian Ridge Country Club (Grove Course) | Palm Desert | CA | 5/3/2021 |
| Patterson Club | Fairfield | CT | 5/3/2021 |
| Plantation Bay Golf & Country Club (Club de Bonmon) | Ormond Beach | FL | 5/3/2021 |
| Marietta Country Club | Kennesaw | GA | 5/3/2021 |
| Beaver Hills Country Club | Cedar Falls | IA | 5/3/2021 |
| Cog Hill Golf & Country Club | Lemont | IL | 5/3/2021 |
| Country Club of Indianapolis | Indianapolis | IN | 5/3/2021 |
| Eastward Ho! | Chatham | MA | 5/3/2021 |
| Muskegon Country Club | Muskegon | MI | 5/3/2021 |
| North Shore Country Club | Glen Head | NY | 5/3/2021 |
| Oak Tree Country Club (East Course) | Edmond | OK | 5/3/2021 |
| The Country Club of Sioux Falls | Sioux Falls | SD | 5/3/2021 |
| Escondido Golf & Lake Club | Horseshoe Bay | TX | 5/3/2021 |
| Alpine Country Club | Highland | UT | 5/3/2021 |
| Gold Mountain Golf Club (Olympic Course) | Bremerton | WA | 5/3/2021 |
| Hot Springs Country Club (Arlington Course) | Hot Springs | AR | 5/4/2021 |
| El Macero Country Club | El Macero | CA | 5/4/2021 |
| Andalusia Country Club | La Quinta | CA | 5/4/2021 |
| Ruby Hill Golf Club | Pleasanton | CA | 5/4/2021 |
| Collindale Golf Course | Ft. Collins | CO | 5/4/2021 |
| Cherry Blossom Golf Club | Georgetown | KY | 5/4/2021 |
| Northwest Golf Course | Silver Spring | MD | 5/4/2021 |
| Legends Club | Prior Lake | MN | 5/4/2021 |
| Green Brook Country Club | North Caldwell | NJ | 5/4/2021 |
| New Mexico State University Golf Course | Las Cruces | NM | 5/4/2021 |
| Beechmont Country Club | Cleveland | OH | 5/4/2021 |
| Whitestone Golf Club | Benbrook | TX | 5/4/2021 |
| RTJ Golf Trail at Silver Lakes | Glencoe | AL | 5/5/2021 |
| The Preserve Golf Club | Carmel | CA | 5/5/2021 |
| Arroyo Trabuco Golf Club | Mission Viejo | CA | 5/5/2021 |
| Orange Tree Golf Club | Orlando | FL | 5/5/2021 |
| Butler Country Club | Butler | PA | 5/5/2021 |
| Sewailo Golf Club | Tucson | AZ | 5/6/2021 |
| Bermuda Dunes Country Club | Bermuda Dunes | CA | 5/6/2021 |
| La Purisima Golf Course | Lompoc | CA | 5/6/2021 |
| Hobe Sound Golf Club | Hobe Sound | FL | 5/6/2021 |
| Bear's Paw Country Club | Naples | FL | 5/6/2021 |
| Bay Point Golf Club (Nicklaus Course) | Panama City Beach | FL | 5/6/2021 |
| Buckhorn Springs Golf & Country Club | Valrico | FL | 5/6/2021 |
| Hillendale Country Club | Phoenix | MD | 5/6/2021 |
| River Landing (River Course) | Wallace | NC | 5/6/2021 |
| The Federal Club | Glen Allen | VA | 5/6/2021 |
| Palmer Golf Course | Palmer | AK | 5/9/2021 |
| Phoenix Country Club | Phoenix | AZ | 5/10/2021 |
| Dragonfly Golf Club | Madera | CA | 5/10/2021 |
| Peach Tree Golf & Country Club | Marysville | CA | 5/10/2021 |
| Classic Club | Palm Desert | CA | 5/10/2021 |
| Walnut Creek Golf Preserve | Westminster | CO | 5/10/2021 |
| Shuttle Meadow Country Club | Kensington | CT | 5/10/2021 |
| Shingle Creek Golf Club | Orlando | FL | 5/10/2021 |
| The Plantation at Ponte Vedra Beach | Ponte Vedra Beach | FL | 5/10/2021 |
| The Club at Weston Hills (Tour Course) | Weston | FL | 5/10/2021 |
| Spencer T. Olin Golf Course | Alton | IL | 5/10/2021 |
| Cantigny Golf Club | Wheaton | IL | 5/10/2021 |
| South Bend Country Club | South Bend | IN | 5/10/2021 |
| Barton Hills Country Club | Ann Arbor | MI | 5/10/2021 |
| Medina Golf & Country Club | Medina | MN | 5/10/2021 |
| Creekmoor Golf Club | Raymore | MO | 5/10/2021 |
| Beatrice Country Club | Beatrice | NE | 5/10/2021 |
| UNM Championship Golf Course | Albuquerque | NM | 5/10/2021 |
| Edgewood Tahoe Golf Course | Stateline | NV | 5/10/2021 |
| Whippoorwill Club |
Armonk | NY | 5/10/2021 |
| Mohawk Golf Club | Schenectady | NY | 5/10/2021 |
| Ravenwood Golf Club | Victor | NY | 5/10/2021 |
| Willamette Valley Country Club | Canby | OR | 5/10/2021 |
| Indian Valley Country Club | Telford | PA | 5/10/2021 |
| Long Cove Club | Hilton Head | SC | 5/10/2021 |
| The Club at Comanche Trace | Kerrville | TX | 5/10/2021 |
| Gamble Sands | Brewster | WA | 5/10/2021 |
| Ironwood Country Club (South Course) | Palm Desert | CA | 5/11/2021 |
| Ledgemont Country Club | Seekonk | MA | 5/11/2021 |
| Missoula Country Club | Missoula | MT | 5/11/2021 |
| The Bridges Golf Club | Gunter | TX | 5/11/2021 |
| Ak-Chin Southern Dunes Golf Club | Maricopa | AZ | 5/12/2021 |
| Wichita Country Club | Wichita | KS | 5/12/2021 |
| The Steel Club | Hellertown | PA | 5/12/2021 |
| Hidden Glen Golf Club | Cedarburg | WI | 5/12/2021 |
| Riverton Country Club | Riverton | WY | 5/12/2021 |
| The Grand Golf Club | San Diego | CA | 5/13/2021 |
| CommonGround Golf Course | Aurora | CO | 5/13/2021 |
| Redhawk Golf Course | Nampa | ID | 5/13/2021 |
| Country Club of York | York | PA | 5/13/2021 |
| The Country Club at DC Ranch | Scottsdale | AZ | 5/17/2021 |
| The Country Club of Winter Haven | Winter Haven | FL | 5/17/2021 |
| Callaway Gardens (Mountainview Course) | Pine Mountain | GA | 5/17/2021 |
| Illini Country Club | Springfield | IL | 5/17/2021 |
| Crumpin-Fox Club | Bernardston | MA | 5/17/2021 |
| Pinewild Country Club (Holly Course) | Pinehurst | NC | 5/17/2021 |
| Las Vegas Paiute Golf Resort | Las Vegas | NV | 5/17/2021 |
| Maketewah Country Club | Cincinnati | OH | 5/17/2021 |
| Catawba Island Club | Port Clinton | OH | 5/17/2021 |
| Kinsale Golf & Fitness Club | Powell | OH | 5/17/2021 |
| Elmhurst Country Club | Moscow | PA | 5/17/2021 |
| Lakeside Country Club | Houston | TX | 5/17/2021 |
| TPC Toronto at Osprey Valley (Heathlands Course) | Caledon, Ontario | CANADA | 5/18/2021 |